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2009 to 2013, after Lexus's mid-cycle update sharpened the styling and interior, and before the third-generation IS arrived. Cars from that window are the more resolved version of this generation.
Not as well as the segment norm, so buy it for the ownership cost rather than the resale. It keeps around 39% of its value after five years, against roughly 52% for the segment and for Lexus's own range — a saloon like this is better bought to keep for a while than to flip.
Comfortably past 150,000 km with routine care. The IS250s we inspect in the UAE run to a median of around 289,000 km with no significant fault pattern, consistent with the naturally aspirated V6's reputation as one of the easier engines in the class to keep running.
The Mercedes C300 holds its value noticeably better and is worth cross-shopping if resale matters to you. The BMW 530 costs more but our inspections find fewer body or panel repairs on it than the class average.