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There is only one generation to choose from so far, so focus on specification and service history rather than model year. A car still under Mercedes warranty is worth paying for given how new this platform is.
The Mercedes E250 is the outgoing coupe this model replaced, and tends to cost less as a result. A BMW 230 is the closest direct rival in size and price. A Ford Mustang undercuts it on price but shows more evidence of prior body or panel repair in our checks — 71% against the 60% we would expect for coupes of this age and mileage here.
Every CLE200 on the used market today is still a young car with light mileage, so long-term durability is best judged by Mercedes' warranty terms and the mild-hybrid system's track record on the closely related C-Class and E-Class it replaces.
Ask for the CarSwitch inspection report even on a near-new CLE200 — it confirms the car matches what the paperwork claims.